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Three Systems, One Shift
12 min readarticle
Claudia is at the doctor. She filled out the PHQ-9 in the waiting room. Nine questions. She averaged. On her good days she would score an 8 — mild. On her bad days she would score a 17 — moderately severe. The questionnaire captures one day. She is living in the oscillation between days, and no sin...
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In this lesson you will learn:
- Estrogen modulates serotonin receptor density (5-HT2A) — when it declines, SSRIs meet fewer receptors (Bethea, OHSU)
- Progesterone converts to allopregnanolone, your brain's natural benzodiazepine — it declines first, often years before estrogen (Backstrom, Umea University)
- Neuroinflammation diverts tryptophan from serotonin production via IDO enzyme — upstream of what SSRIs can reach (2024 J Neuroinflammation)
- +2 more takeaways
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