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The Inflammatory Pathway Nobody Mentions
11 min readarticle
It is lunchtime and Claudia is reading about neuroinflammation on her phone. She is eating a salad she does not taste at her desk in the nonprofit office. The irony is almost unbearable at this point: the nonprofit posts about hormone health. She writes the captions. She knows the words — estrogen,...
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In this lesson you will learn:
- Estrogen decline activates NF-kB → microglia shift M2→M1 → release TNF-alpha, IL-1-beta, IL-6 (Journal of Neuroinflammation, 2024)
- Inflammatory cytokines activate IDO, diverting tryptophan from serotonin → quinolinic acid (neurotoxic). Two insults, one mechanism.
- SSRI non-response explained: blocking reuptake of a neurotransmitter being manufactured at reduced capacity
- +2 more takeaways
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