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The Gut Knew First
11 min readarticle
Claudia reads about the gut-brain axis for the first time on a Wednesday evening. Marcus is doing bedtime. She is sitting at the kitchen table with her laptop open and a glass of water she now drinks instead of her fourth coffee. 95% of serotonin is made in the gut. She reads it again. Ninety-five...
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In this lesson you will learn:
- 95% of serotonin is made in the gut. The tryptophan pathway requires dietary precursors (turkey, salmon, eggs, nuts) plus cofactors (B6, folate, iron, zinc)
- Estrogen decline reduces gut microbiome diversity via the estrobolome, compromising serotonin synthesis — a bidirectional loop
- EPA (not DHA alone) at 1-2g/day is recommended by ISNPR as adjunctive treatment for major depression. Anti-inflammatory mechanism.
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